Breakthrough COVID Cases Overwhelmingly Mild for Vaccinated People: Study

Written by Diane Mooy and Stephen Reinberg, HealthDay Reporters>

Friday, January 7, 2022 – A review of cases from 465 hospitals in the United States confirms the protection provided by COVID-19 vaccines.

The new review – conducted by researchers at the US National Institutes of Health – found that vaccinated adults who develop an unprecedented infection rarely develop serious illness. Cases of respiratory failure, the need for treatment in the intensive care unit, and death were extremely rare.

“Vaccines are highly effective and significantly reduce the risk of severe COVID-19 outcomes,” said lead researcher Dr. Samir Qadri, chief of clinical epidemiology in the Division of Critical Care Medicine at the National Institutes of Health Center in Bethesda, Maryland.

The data covered a period between March 2020 and October 2021 when the severe delta variant of SARS-CoV-2 spread in the United States.

Omicron, the alternative that is better at evading immunity but results in less severe disease, has not been shown.

The review included data from 1.2 million people who were fully vaccinated against COVID.

The study found that people at risk of serious illness or death include people 65 and older, as well as people with weakened immune systems or chronic diseases, such as those affecting the kidneys, heart, lungs, liver, or nervous system. .

According to the study, for every 10,000 patients vaccinated with the Corona virus, 1.5 died, and 18 of them had serious outcomes. All of those who experienced a serious outcome had at least one risk factor, and about 8 in 10 of those who died had four or more.

In addition to getting two doses of the Pfizer or Moderna vaccine or one Johnson & Johnson vaccine, the booster injections provide more protection, the researchers noted.

The US Centers for Disease Control and Prevention recommends Moderna and J&J boosters for people age 18 and older and Pfizer boosters for everyone age 12 and older.

“Increasing vaccination coverage against COVID-19 is a public health priority,” Qadri said, adding that vaccines may not only slow the spread of the virus but also help prevent the emergence of new variants.

For people who have been vaccinated with the COVID virus, treatment with a monoclonal antibody can effectively reduce the severity of the infection, the researchers said.

They added that as new types of the virus emerge, it will be important to develop new treatments for those who have already been vaccinated, especially for those at high risk of serious disease.

Several steps can help reduce the risk of serious disease.

“To reduce the risk of severe COVID-19 outcomes, vaccinated people 65 years of age or older, or people who are immunocompromised or have other underlying conditions, should receive chronic disease management care, and take precautions to reduce exposure, Such as wearing a mask and walking away, getting extra doses of the initial and booster vaccine, and getting effective drug therapy as needed.”

Infectious disease expert Dr. Mark Siegel is a clinical professor of medicine at NYU Langone Medical Center in New York City. He said increasing vaccination rates is a critical public health priority.

“We need to vaccinate the masses of people, because it reduces acute outcomes and maybe reduces spread to some extent, and more people have mild disease,” Siegel said.

And urge to get a booster shot when you qualify for it. These steps will help make your COVID-19 situation milder if you do get a breakthrough infection.

“Make sure your vaccine is up to date, and your boosters are up to date — everything you have is maximized,” Siegel said.

He warned of the emergence of more types of virus. But because the Omicron variant is highly contagious, it may suppress others.

What is needed is a vaccine that prevents the Omicron variant, Siegel said.

“I feel very strongly that Pfizer and Moderna should retool the Omicron vaccine,” Siegel said. “They are, but it’s too slow.”

The new study was published Jan. 7 in the Centers for Disease Control and Prevention Weekly morbidity and mortality report.

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