New opportunity to induce remission of peanut allergy in young children through oral immunotherapy

A clinical trial funded by the National Institutes of Health found that giving a peanut immunotherapy to children with severe peanut allergies between the ages of 1 and 3 years safely removes allergies to mostly peanuts and induces remission of peanut allergies in five. Immunotherapy consisted of a daily oral dose of peanut flour for … Read more

Ketamine plus psychological therapy can help people stay off alcohol for longer time

People with severe alcohol use disorder were able to stay off alcohol for longer when treated with low doses of ketamine with psychotherapy in a clinical trial. The University of Exeter led the Ketamine Alcohol Relapse Reduction Trial (KARE) and was funded by the Medical Research Council. The phase two trial is the first of … Read more

Clinical trial shows preliminary efficacy of all-oral regimen for patients with lenalidomide-refractory multiple myeloma

Early results from the Clinical Trials Alliance in Oncology randomized clinical trials of adults with relapsing multiple myeloma in frontline treatment of lenalidomide show that adding ixazomib (Ninlaro®) to pomalidomide and dexamethasone as part of second-line treatment prolonged the time patients lived before being treated. . Exacerbation of disease (progression-free survival) compared to patients who … Read more

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Using a synthetic short chain of chemically modified nucleotides engineered at the Institute of RNA Therapeutics at UMass Chan School of Medicine, Robert H. The ALS gene known as C9ORF72 in a pilot study of a single patient. C9ORF72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and familial frontotemporal dementia (FTD). … Read more